Áreas de Trabajo
BIOCHEMICAL AND MOLECULAR BIOLOGY STUDIES ON THE MICROBIAL SYNTHESIS OF SECONDARY METABOLITES.
Secondary metabolites are compounds with a wide range of chemical structures and biological activities synthesized by a few range of microorganisms usually at the late growth phase. Although involved in different functions (signalling differentiation, mediating ecological interactions and facilitating biochemical evolution in microorganisms), these metabolites are considered as secondary since are not essential for microbial growth. The remarkable diversity of biological functions and chemical structures characteristic of these metabolites reflects the random manner in which their biosynthesis has evolved and been exploited. It represents a form of inventive evolution in which metabolic opportunities that arose by chance were exploited and incorporated to various degrees into the phenotype of the species. Therefore it has been interesting for us to elucidate, at the biochemical and molecular biology levels, how these microorganisms are able to synthesize and regulate the production of these compounds. The impact of these studies can be situated at the general microbiology level, but also from the biotechnology standpoint since the resulting knowledge can be used to design rational genetic improvement and process optimization of secondary metabolites production.
PLANT-ASSOCIATED MICROBIAL SYSTEMS AS A SOURCE OF BIOLOGICALLY ACTIVE COMPOUNDS.
Plants and microorganisms synthesize most of the secondary metabolites with biological activity. Almost 50% of the biopharmaceutical have been obtained from plants. Plan-associated microorganisms (endophytic) such as bacteria or fungi produce many of these secondary metabolites. One endophytic fungi is Taxomyces andreanae, able to produce the anticancer drug, Taxol. Other endophytics have been shown to produce compounds with antibacterial, antiviral, antifungal and antimalarial activity. We are interested in the evaluation of medicinal plants as source of endophytic microorganisms as a way to look for new biologically active compounds.
Publicaciones Recientes
Reyna-Campos AO, Ruiz-Villafan B, Macías-Rubalcava ML, Langley E, Rodríguez-Sanoja R, Sánchez S.
Heterologous expression of lasso peptides with apparent participation in the morphological development in Streptomyces.
Appl. Microbiol. Biotechnol. Express. 14:97. DOI: 10.1186/s13568-024-01761-w
2024
Roblero-Mejía DO, García-Ausencio C, Rodríguez-Sanoja R, Guzmán-Chávez F, Sánchez S.
Embleporicin: A novel class I lanthipeptide from the actinobacteria Embleya sp. NF3.
Antibiotics. 13:1179. DOI: 10.3390/antibiotics13121179
2024
Cruz-Bautista, R., Zelarayan-Agüero, A., Ruiz-Villafán, B., Escalante-Lozada, A., Rodríguez-Sanoja, R., & Sánchez, S.
An overview of the two-component system GarR/GarS role on antibiotic production in Streptomyces coelicolor.
Applied microbiology and biotechnology, 108(1), 306. DOI: 10.1007/s00253-024-13136-z
2024
Kumar Passari A, Ruiz-Villafán B, Cruz-Bautista R, Díaz-Domínguez V, Rodríguez-Sanoja R, Sánchez S.
Opportunities and challenges of microbial siderophores in the medical field.
Appl Microbiol Biotechnol. 107: 6751-6759. DOI: 10.1007/s00253-023-12742-7.
2023
Ramirez-Rendon D, Guzmán-Chávez F, García-Ausencio C, Rodríguez-Sanoja R, Sánchez S.
The untapped potential of actinobacterial lanthipeptides as therapeutic agents.
Mol Biol Rep. 50: 0175-7598. (12 pag) DOI: 10.1007/s11033-023-08880-w
2023
Estudiantes
| Nombre | Nivel |
|---|---|
| Alma Reyna Campos | Doctorado |
| Berenice Hernandez Cordero | Doctorado |
| Carlos Adrian García Ausencio | Doctorado |
| Jesus Emiliano Campoy Román | Doctorado |
| Gladys Vega Sauceda | Maestría |
| Thalía Serrano Munguía | Maestría |
| Valerie Díaz Domínguez | Maestría |
| Yvette Ximena González López | Maestría |
| Alinne García García | Licenciatura |
| Paola Ortega Becerril | Licenciatura |
| Sofia Castañeda Flores | Licenciatura |
| Tamara Estrada Garcés | Licenciatura |
| Kendrick Figueroa Jaimes | Servicio Social |
| Melani Becerril Villanueva | Servicio Social |
| Alejandro Guerrero Zuñiga | Servicio Social |