Áreas de Trabajo
Nongenomic Effects of Steroid Hormones on Smooth Muscle.
The research work in this laboratory is in the effect and mechanism of action of steroid hormones. More specifically, we are interested in the membrane (non-genomics) mechanism by which the steroids are inducing rapid changes on the tissue excitability. Since 20 years ago, we have studied the relaxing effect and mechanism of action of 5alpha- and 5beta-reduced androgens and progestins on smooth muscle contractility, using as principal model the uterus of rats and humans. Additionally, we have reported that other smooth muscles such as: vascular, intestinal and airway are also relaxed by these steroids. In this context, our experiments have showed that the relaxing effect of steroids is non-genomically mediated, and it may be explained in terms of a blockade of voltage- and receptor-dependent calcium channels, a mechanism that restricts the availability of extracellular calcium in the contractile machinery.
Publicaciones Recientes
Montaño L.M.; Flores-Soto, Edgar; Sommer, Bettina; Solis-Chagoyan, Hector; Perusquia, Mercedes
Androgens are effective bronchodilators with anti-inflammatory properties: A potential alternative for asthma therapy
Steroids, Volume 153 DOI: 10.1016/j.steroids.2019.108509
2020
Perusquia, Mercedes; Hanson, Andrea E.; Stallone, John N.
Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens
Biology Of Sex Differences, Volume 11 Número 1 DOI: 10.1186/s13293-020-00324-5
2020
Perusquia, M; Contreras, D; Herrera, N
Hypotestosteronemia is an important factor for the development of hypertension: elevated blood pressure in orchidectomized conscious rats is reversed by different androgens
Endocrine 65(2):416-425. F.I. 3.296
2019
Perusquia, M; Hanson, AE; Meza, CM; Kubli, C; Herrera, N; Stallone, JN.
Antihypertensive responses of vasoactive androgens in an in vivo experimental model of preeclampsia.
J Steroid Biochem Mol Biol. (2018), 178:65-72. FI. 4.095
2018
Isidoro, L; Ferrer, M; Perusquia, M.
Vasoactive androgens: Vasorelaxing effects and their potential regulation of blood pressure.
Endocrin Res. (2018), 43(3):166-175. FI. 1.518
2018
Estudiantes
| Nombre | Nivel |
|---|---|
| Lucía Isidoro García | Doctorado |
| David García Hernández | Licenciatura |
| Sandra Bernal Zambrano | Licenciatura |